6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

Base Information

Chemical Name:6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine
CAS No.:1334215-11-0
Molecular Formula:C₁₉H₁₄ClN₃O₃
Molecular Weight:367.791
Hs Code.:

Synonyms:6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

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Chemical Property of 6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

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Technology Process of 6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

There total 9 articles about 6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1334215-10-9
6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 1334215-11-0
6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

Guidance literature:: With triethylamine; In dichloromethane; at 5 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.tet.2011.07.083

Reference yield:

: 249608-70-6
(2-aminophenyl)(1H-pyrrol-2-yl)methanone

: 1334215-11-0
6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / toluene / 1 h / 10 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

3: Raney nickel / ethanol / 0.08 h / Reflux

4: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 1 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 5 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.07.083

Reference yield:

: 249608-72-8
(2-isothiocyanatophenyl)(1H-pyrrol-2-yl)methanone

: 1334215-11-0
6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2: Raney nickel / ethanol / 0.08 h / Reflux

3: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 5 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.07.083