3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

Base Information

Chemical Name:3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline
CAS No.:1334215-12-1
Molecular Formula:C₁₉H₁₆ClN₃O
Molecular Weight:337.809
Hs Code.:

Synonyms:3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

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Chemical Property of 3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

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Technology Process of 3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

There total 11 articles about 3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1334215-11-0
6-(2-chloro-4-nitrobenzoyl)-6,11-dihydro-5H-pyrrolo[1,2-c][1,3]benzodiazepine

: 1334215-12-1
3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

Guidance literature:: With ammonium chloride; zinc; In ethanol; water; at 20 ℃; for 18h;
DOI:10.1016/j.tet.2011.07.083

Reference yield:

: 249608-70-6
(2-aminophenyl)(1H-pyrrol-2-yl)methanone

: 1334215-12-1
3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / toluene / 1 h / 10 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

3: Raney nickel / ethanol / 0.08 h / Reflux

4: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 1 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 5 - 20 °C / Inert atmosphere

6: ammonium chloride; zinc / ethanol; water / 18 h / 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2011.07.083

Reference yield:

: 249608-72-8
(2-isothiocyanatophenyl)(1H-pyrrol-2-yl)methanone

: 1334215-12-1
3-chloro-4-(5H-pyrrolo[1,2-c][1,3]benzodiazepin-6(11H)-ylcarbonyl)aniline

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C / Inert atmosphere

2: Raney nickel / ethanol / 0.08 h / Reflux

3: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 5 - 20 °C / Inert atmosphere

5: ammonium chloride; zinc / ethanol; water / 18 h / 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; potassium carbonate; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2011.07.083