(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Base Information

Chemical Name:(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate
CAS No.:1410811-14-1
Molecular Formula:C₂₀H₂₅BrN₂O₅
Molecular Weight:453.333
Hs Code.:

Synonyms:(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

There total 7 articles about (S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(bromoethynyl)benzoic acid

: (S)-methyl 2-amino-3-(((tert-butoxy)carbonyl)amino)-3-methylbutanoate oxalate

: 1410811-14-1
(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Guidance literature:: (S)-methyl 2-amino-3-(((tert-butoxy)carbonyl)amino)-3-methylbutanoate oxalate; With potassium carbonate; In water; ethyl acetate; for 0.166667h; Cooling with ice;

4-(bromoethynyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 1093192-07-4
(S)-2-amino-3-(tert-butoxycarbonylamino)-3-methylbutanoic acid methyl ester

: 4-(bromoethynyl)benzoic acid

: 1410811-14-1
(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

: 75867-41-3
4-trimethylsilanylethynyl-benzoic acid methyl ester

: 1410811-14-1
(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; potassium hydroxide / 0.08 h / 10 - 20 °C

2.1: silver nitrate / acetone / 1 h

2.2: 20 h / 20 °C

3.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 25 °C

4.1: potassium carbonate / ethyl acetate; water / 0.17 h / Cooling with ice

4.2: 2 h / 0 - 20 °C

With methanol; water; potassium carbonate; silver nitrate; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; acetone;