(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Base Information

Chemical Name:(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate
CAS No.:1410809-75-4
Molecular Formula:C₂₆H₃₂N₂O₆
Molecular Weight:468.55
Hs Code.:

Synonyms:(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Chemical Property of (2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

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Technology Process of (2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

There total 3 articles about (2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1410811-14-1
(S)-methyl 2-(4-(2-bromoethynyl)benzamido)-3-((tert-butoxycarbonyl)amino)-3-methylbutanoate

: 144478-66-0
(2-ethynylcyclopropyl)methanol

: 1410809-75-4
(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: With N-butylamine; hydroxylamine hydrochloride; copper(l) chloride; In tetrahydrofuran; methanol; for 4h; Inert atmosphere;

Reference yield:

: 13949-93-4,13950-12-4,77183-91-6,77183-92-7,109716-50-9,109716-61-2,20417-61-2
ethyl-2-formyl-1-cyclopropane carboxylate

: 1410809-75-4
(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; methanol / 18 h / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

3: N-butylamine / hydroxylamine hydrochloride; copper(l) chloride / tetrahydrofuran; methanol / 4 h / Inert atmosphere

With methanol; lithium aluminium tetrahydride; potassium carbonate; N-butylamine; hydroxylamine hydrochloride; copper(l) chloride; In tetrahydrofuran; methanol;

Reference yield:

: 71331-07-2
ethyl 2-ethynylcyclopropanecarboxylate

: 1410809-75-4
(2S)-methyl 3-(tert-butoxycarbonylamino)-2-(4-((2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

2: N-butylamine / hydroxylamine hydrochloride; copper(l) chloride / tetrahydrofuran; methanol / 4 h / Inert atmosphere

With lithium aluminium tetrahydride; N-butylamine; hydroxylamine hydrochloride; copper(l) chloride; In tetrahydrofuran; methanol;