N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide

Base Information

• Chemical Name: N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide
• CAS No.: 1315322-99-6
• Molecular Formula: C₁₇H₁₀ClF₆N₃O₂S
• Molecular Weight: 469.795
• Mol file: 1315322-99-6.mol

Synonyms:N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide

Chemical Property of N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide

There total 4 articles about N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chlorobenzenesulfonyl chloride (98-60-2) + 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline (123066-64-8) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide (1315322-99-6)

Guidance literature:

With pyridine; In acetonitrile; at 100 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/jo2009824

Reference yield:

1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one (1694-30-0) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide (1315322-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: pyridine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; palladium 10% on activated carbon; cyclohexene; In ethanol; water; acetonitrile;

DOI:10.1021/jo2009824

Reference yield:

4-nitrophenylhydrazine hydrochloride (636-99-7) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-chlorobenzenesulfonamide (1315322-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: pyridine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; palladium 10% on activated carbon; cyclohexene; In ethanol; water; acetonitrile;

DOI:10.1021/jo2009824

upstream raw materials:

1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one

4-nitrophenylhydrazine hydrochloride

1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole

4-chlorobenzenesulfonyl chloride