[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Base Information

Chemical Name:[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate
CAS No.:1280665-76-0
Molecular Formula:C₁₅H₂₄N₄O₆
Molecular Weight:356.379
Hs Code.:

Synonyms:[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Suppliers and Price of [(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

There total 5 articles about [(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1280665-75-9
tert-butyl N-[(1R,2R,4R,5R)-4-azido-2,5-dihydroxy-cyclohexyl]carbamate

: 108-24-7
acetic anhydride

: 1280665-76-0
[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Guidance literature:: With pyridine; for 3h; Inert atmosphere;

Reference yield:

: 1165952-92-0
cyclohexa-1,4-diene

: 1280665-76-0
[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / Inert atmosphere

2: sodium azide; ammonium chloride / water; methanol / 2 h / Inert atmosphere; Reflux

3: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / Inert atmosphere

4: ammonia / ethanol; water / 16 h / 20 - 30 °C / Inert atmosphere; Reflux

5: triethylamine / dichloromethane / 3 h / Inert atmosphere

6: pyridine / 3 h / Inert atmosphere

With pyridine; sodium azide; ammonia; sodium hydrogencarbonate; ammonium chloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; ethanol; dichloromethane; water;

Reference yield:

: (1S,3R,4R)-4-azido-7-oxabicyclo[4.1.0]heptan-3-ol

: 1280665-76-0
[(1R,2R,4R,5R)-4-acetoxy-2-azido-5-(tert-butoxycarbonylamino)cyclohexyl] acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / ethanol; water / 16 h / 20 °C / Reflux

2.1: triethylamine / dichloromethane / 3 h

2.2: pH 3 - 4

3.1: pyridine / 3 h

3.2: pH 3 - 4

With pyridine; triethylamine; ammonia; In ethanol; dichloromethane; water;