benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Base Information

Chemical Name:benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate
CAS No.:1569905-93-6
Molecular Formula:C₄₀H₄₁F₃N₂O₆
Molecular Weight:702.771
Hs Code.:

Synonyms:benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Chemical Property of benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

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Technology Process of benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

There total 11 articles about benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₃₅F₃N₂O₆

: 100-39-0
benzyl bromide

: 1569905-93-6
benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1055/s-0033-1339892

Reference yield:

: C₂₃H₃₂F₃NO₅

: 1569905-93-6
benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

2.3: -78 - 30 °C / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 2.5 h / 0 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol; water / 6 h

5.1: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With n-butyllithium; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0033-1339892

Reference yield:

: C₁₈H₂₃F₃N₄O₄

: 1569905-93-6
benzyl (2R)-3-[2-(3-{[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol; water / 6 h

2: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

3: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1339892