methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

Base Information

Chemical Name:methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate
CAS No.:1569905-48-1
Molecular Formula:C₁₄H₁₄BrF₃O₂
Molecular Weight:351.163
Hs Code.:

Synonyms:methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

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Chemical Property of methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

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Technology Process of methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

There total 1 articles about methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 444-29-1
2-iodo(trifluoromethyl)benzene

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 109-64-8
1,3-dibromo-propane

: 1569905-48-1
methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

Guidance literature:: With norbornene; palladium diacetate; caesium carbonate; triphenylphosphine; In acetonitrile; at 90 ℃; for 18h; Sealed tube; Inert atmosphere;
DOI:10.1055/s-0033-1339892

Reference yield: 91.0%

: 51779-32-9
iminodicarboxylic acid di-tert-butyl ester

: 1569905-48-1
methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

: 1569905-58-3
methyl (2E)-3-[2-(3-{bis[(tert-butoxy)carbonyl]amino}propyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; Sealed tube;
DOI:10.1055/s-0033-1339892

Reference yield:

: 1569905-48-1
methyl (2E)-3-[2-(3-bromopropyl)-6-(trifluoromethyl)phenyl]prop-2-enoate

: C₃₃H₃₅F₃N₂O₆

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 90 °C / Sealed tube

2.1: hydrogen; palladium 10% on activated carbon / methanol / 8 h

3.1: sodium hydroxide / methanol; water / 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

5.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

5.2: -78 - 20 °C / Inert atmosphere

6.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere

6.2: -78 °C / Inert atmosphere

6.3: -78 - 30 °C / Inert atmosphere

7.1: dihydrogen peroxide; lithium hydroxide / water; tetrahydrofuran / 2.5 h / 0 °C

8.1: hydrogen; palladium 10% on activated carbon / methanol; water / 6 h

9.1: sodium hydrogencarbonate / water; 1,4-dioxane / 0 - 20 °C

With n-butyllithium; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; sodium hydrogencarbonate; caesium carbonate; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-0033-1339892