Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Base Information

• Chemical Name: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
• CAS No.: 153888-47-2
• Molecular Formula: C₈H₈BrNO₃
• Molecular Weight: 246.06
• Mol file: 153888-47-2.mol

Synonyms:methyl 5 -bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Chemical Property of Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Chemical Property:

• Boiling Point: 325.4±42.0 °C(Predicted)
• PKA: -4.45±0.62(Predicted)
• Density: 1.656±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

95+% ^*data from raw suppliers

Methyl5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate is a starting material in the synthesis of Functionalized Tricyclic Pyrrolo-Pyridones

Technology Process of Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

There total 4 articles about Methyl 5-bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate (381247-99-0) + methyl iodide (74-88-4) → methyl 5 -bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (153888-47-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01871

Reference yield: 73.0%

5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylic acid (41668-13-7) + methyl iodide (74-88-4) → methyl 5 -bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (153888-47-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield:

methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (6375-89-9) → methyl 5 -bromo-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (153888-47-2)

Guidance literature:

With N-Bromosuccinimide; In acetic acid; at 80 ℃; for 4h;

upstream raw materials:

methyl 1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

methyl 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylate

methyl iodide

5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Downstream raw materials:

methyl 5-(2,6-difluorophenyl)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate