381247-99-0

Basic information

• Product Name: METHYL 5-BROMO-6-HYDROXYNICOTINATE
• Synonyms: METHYL 5-BROMO-6-HYDROXYNICOTINATE;Methyl 5-broMo-6-hydroxypyridine-3-carboxylate;Methyl 3-bromo-2-hydroxypyridine-5-carboxylate;3-Pyridinecarboxylic acid, 5-broMo-1,6-dihydro-6-oxo-, Methyl ester;5-BroMo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid Methyl ester;Methyl 5-bromo-6-hydroxypyridine-3-carboxylate, Methyl 5-bromo-1,6-dihydro-6-oxopyridine-3-carboxylate, 3-Bromo-2-hydroxy-5-(methoxycarbonyl)pyridine;Methyl5-bromo-6-hydroxynicotinate95%
• CAS NO: 381247-99-0
• Molecular Formula: C₇H₆BrNO₃
• Molecular Weight: 232.03
• Product Categories: Esters;Pyridines
• Mol File: 381247-99-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 225-227℃
• Boiling Point: 353.1°C at 760 mmHg
• Flash Point: 167.4°C
• Appearance: White to pale brown/Solid
• Density: 1.737g/cm³
• Vapor Pressure: 3.66E-05mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: 2-8°C
• PKA: 8.50±0.10(Predicted)
• CAS DataBase Reference: METHYL 5-BROMO-6-HYDROXYNICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 5-BROMO-6-HYDROXYNICOTINATE(381247-99-0)
• EPA Substance Registry System: METHYL 5-BROMO-6-HYDROXYNICOTINATE(381247-99-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 381247-99-0(Hazardous Substances Data)

Usage

Form

White to pale brown solid

Uses

METHYL 5-BROMO-6-HYDROXYNICOTINATE is a useful research chemical.

InChI:InChI=1/C7H6BrNO3/c1-12-7(11)4-2-5(8)6(10)9-3-4/h2-3H,1H3,(H,9,10)

Upstream product

• 67-56-1 methanol 
• 41668-13-7 5-bromo-6-oxo-1,6-dihydropyridine-3-carboxylic acid 
• 41668-13-7 5-bromo-6-hydroxy-3-pyridinecarboxylic acid 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 66171-50-4 methyl 6-hydroxynicotinate 
• 42933-07-3 methyl 3-bromo-2-oxo-2H-pyran-5-carboxylate 

Downstream Products

• 78686-81-4 methyl 5,6-dibromonicotinate 
• 78686-77-8 5-bromo-6-chloro-3-pyridinecarboxylic acid methyl ester 
• 93349-99-6 methyl 5-bromo-6-methoxy-pyridine-3-carboxylate 
• 234107-97-2 methyl 6-methoxy-5-methylnicotinate 
• 398145-63-6 3-bromo-5-methoxycarbonyl-1-(4-methylbenzenesulfonyl)-2(1H)-pyridone 
• 41668-13-7 5-bromo-6-hydroxy-3-pyridinecarboxylic acid 

Relevant articles and documents

De novo Design of SARS-CoV-2 Main Protease Inhibitors

The COVID-19 pandemic prompted many scientists to investigate remedies against SARS-CoV-2 and related viruses that are likely to appear in the future. As the main protease of the virus, M Pro, is highly conserved among coronaviruses, it has emerged as a prime target for developing inhibitors. Using a combination of virtual screening and molecular modeling, we identified small molecules that were easily accessible and could be quickly diversified. Biochemical assays confirmed a class of pyridones as low micromolar noncovalent inhibitors of the viral main protease.

TAM family kinase and/or CSF1R kinase inhibitor and application thereof

The invention provides a novel inhibitor compound shown in a general formula (I). The compound has good kinase inhibition activity and can be used for preventing and/or treating diseases mediated by abnormal expression of TAM family kinase and/or a ligand thereof. The compound can target CSF1R kinase and can be used for preventing and/or treating diseases mediated by abnormal expression of a TAM family kinase receptor and/or a CSF1R kinase receptor and/or ligands thereof.

PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS

There are provided inter alia pyrazolyl-substituted pyridone compounds, which exhibit biological activity, e.g., inhibitory action, against serine proteases, including thrombin and various kallikreins. There are additionally provided pharmaceutical compositions. There are additionally provided methods of treating and preventing certain diseases or disorders, which disease or disorder is amenable to treatment or prevention by the inhibition of serine proteases, including thrombin and various kallikreins.