Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Base Information

Chemical Name:Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside
CAS No.:134040-59-8
Molecular Formula:C₃₃H₄₄Cl₆N₂O₁₃
Molecular Weight:889.436
Hs Code.:

Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Synonyms:Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Suppliers and Price of Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

There total 10 articles about Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

: 134040-58-7
Allyl 4-O-benzyl-6-O-(2-chloroacetylamino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

: 134040-59-8
Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Guidance literature:: With 4 A molecular sieve; N-ethyl-N,N-diisopropylamine; thiourea; In tetrahydrofuran; at 55 ℃;
DOI:10.1248/cpb.39.288

Reference yield:

: 66270-36-8
2,2,2-trichloro-1,1-dimethylethoxychloroformate

: 134040-59-8
Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 9 steps

1: 97.3 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

2: 97 percent / 90 percent aq. acetic acid / 90 °C

3: 93.6 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 86.1 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / Ambient temperature

5: 95 percent / NH₄OH-MeOH-THF (1:9:1) / 4 h / Ambient temperature

6: 84.1 percent / 1,1,3,3-tetramethylurea, molecular sieves 4A, FeCl₃ / CH₂Cl₂ / Ambient temperature

7: 95.2 percent / NH₄OH-MeOH (1:10) / Ambient temperature

8: 95.4 percent / p-toluenesulfonic acid / dimethylformamide / Ambient temperature

9: 84.6 percent / thiourea, diisopropylethylamine, molecular sieves 4A / tetrahydrofuran / 55 °C

With tetrahydrofuran; pyridine; methanol; dmap; ammonium hydroxide; trifluorormethanesulfonic acid; 4 A molecular sieve; iron(III) chloride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; thiourea; tetramethylurea; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.288

Reference yield:

: 97562-24-8
allyl 2-deoxy-4,6-O-isopropylidene-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

: 134040-59-8
Allyl 6-O-(2-amino-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranosyl)-4-O-benzyl-2-deoxy-3-O-(2,2,2-trichloro-tert-butoxycarbonyl)-2-(2,2,2-trichloroethoxycarbonylamino)-α-D-glucopyranoside

Guidance literature:: Multi-step reaction with 9 steps

1: 97.3 percent / pyridine, 4-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

2: 97 percent / 90 percent aq. acetic acid / 90 °C

3: 93.6 percent / pyridine / CH₂Cl₂ / 1 h / 0 °C

4: 86.1 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / Ambient temperature

5: 95 percent / NH₄OH-MeOH-THF (1:9:1) / 4 h / Ambient temperature

6: 84.1 percent / 1,1,3,3-tetramethylurea, molecular sieves 4A, FeCl₃ / CH₂Cl₂ / Ambient temperature

7: 95.2 percent / NH₄OH-MeOH (1:10) / Ambient temperature

8: 95.4 percent / p-toluenesulfonic acid / dimethylformamide / Ambient temperature

9: 84.6 percent / thiourea, diisopropylethylamine, molecular sieves 4A / tetrahydrofuran / 55 °C

With tetrahydrofuran; pyridine; methanol; dmap; ammonium hydroxide; trifluorormethanesulfonic acid; 4 A molecular sieve; iron(III) chloride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; thiourea; tetramethylurea; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.288