4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Base Information

Chemical Name:4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine
CAS No.:141309-93-5
Molecular Formula:C₂₂H₂₀ClN₃
Molecular Weight:361.874
Hs Code.:

Synonyms:4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Suppliers and Price of 4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

There total 4 articles about 4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 135689-67-7
5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidin-4(3H)-one

: 141309-93-5
4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Guidance literature:: With trichlorophosphate; at 100 ℃; for 6h;
DOI:10.1021/jm00041a016 DOI:10.1016/0223-5234(96)88246-8

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 141309-93-5
4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

With sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; toluene;
DOI:10.1002/jhet.5570330450

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 141309-93-5
4-chloro-5-<(2'-cyanobiphenyl-4-yl)methyl>-2-methyl-6-n-propylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: LiCl, (i-Pr)2NEt / tetrahydrofuran / 15 h / Heating

2: NaOMe / methanol / a) RT, 20 h, b) reflux, 2 h

3: POCl₃ / toluene / 8 h / Heating

With sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; trichlorophosphate; In tetrahydrofuran; methanol; toluene;
DOI:10.1002/jhet.5570330450