2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

Base Information

Chemical Name:2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol
CAS No.:1427407-25-7
Molecular Formula:C₁₉H₁₃ClF₃NO
Molecular Weight:363.767
Hs Code.:

Synonyms:2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

Chemical Property:

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Technology Process of 2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

There total 9 articles about 2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1427407-24-6
N-(2-chloro-6-fluoro-3-hydroxy-phenyl)-2-fluoro-5-(3-fluorophenyl)benzamide

: 1427407-25-7
2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 - 60 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427407-25-7
2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

With borane-THF; sodium hydrogencarbonate; In tetrahydrofuran;

Reference yield:

: 886499-40-7
2-chloro-6-fluoro-3-methoxy-benzoic acid

: 1427407-25-7
2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

1.2: 0 - 70 °C

2.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

4.1: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

With borane-THF; oxalyl dichloride; boron tribromide; sodium hydrogencarbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;