1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

Base Information

Chemical Name:1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride
CAS No.:1357270-60-0
Molecular Formula:C₂₃H₂₁N₃*ClH
Molecular Weight:375.901
Hs Code.:

Synonyms:1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

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Chemical Property of 1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

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Technology Process of 1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

There total 6 articles about 1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1357159-08-0
tert-butyl 1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutylcarbamate

: 1357270-60-0
1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 25 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm201394e

Reference yield:

: 1032349-96-4
tert-butyl [1-(4-chlorophenyl)cyclobutyl]carbamate

: 1357270-60-0
1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

2.1: tetrahydrofuran / -78 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 25 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.2: 4 h / 25 °C / Inert atmosphere

5.1: ammonia / methanol / 1.5 h / 140 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With hydrogenchloride; pyridinium hydrobromide perbromide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; ammonia; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201394e

Reference yield:

: 1355999-71-1
tert-butyl 1-(4-(2-bromo-2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1357270-60-0
1-(4-(4-phenylpyrrolo[1,2-a]pyrazin-3-yl)phenyl)cyclobutanamine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 25 °C / Inert atmosphere

2.1: ammonia / methanol / 1.5 h / 140 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 25 °C / Inert atmosphere

With hydrogenchloride; ammonia; potassium carbonate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm201394e