diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate

Base Information

• Chemical Name: diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate
• CAS No.: 149194-43-4
• Molecular Formula: C₃₂H₂₉N₂O₇P
• Molecular Weight: 584.565
• Mol file: 149194-43-4.mol

Synonyms:diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate

Chemical Property of diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate

There total 5 articles about diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

triphenyl phosphite (101-02-0) + 4-phthalimidobutanal (3598-60-5) + O-benzyl carbamate (621-84-1) → diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate (149194-43-4)

Guidance literature:

With acetic acid; at 90 ℃; for 2h;

DOI:10.1021/jm0499209

Reference yield:

N-(4-hydroxybutyl)phthalimide (24697-70-9) → diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate (149194-43-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) (COCl)2, DMSO, 2.) DIEA / 1.) CH₂Cl₂, -45 deg C, 15 min, 2.) CH₂Cl₂, -30 deg C, 30 min

2: 47 percent / HOAc / 1 h / 80 - 90 °C

With oxalyl dichloride; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;

DOI:10.1021/jm970543s

Reference yield:

phthalic anhydride (85-44-9) → diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate (149194-43-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NEt₃ / toluene

2: dil HCl / Ambient temperature

3: 55 percent / acetic acid / 1 h / 80 - 85 °C

With hydrogenchloride; triethylamine; In acetic acid; toluene;

DOI:10.1016/S0040-4039(00)73578-7

upstream raw materials:

triphenyl phosphite

4-phthalimidobutanal

O-benzyl carbamate

phthalic anhydride

Downstream raw materials:

C₃₅H₄₅N₄O₉P

diphenyl ((N-benzyloxycarbonyl-O-tert-butyl-D-seryl)-L-alanyl)amino-(3-(N,N'-bis(tert-butyloxycarbonyl)guanyl)propyl)methanephosphonate

diphenyl (N-benzyloxycarbonyl-L-alanyl)amino-(3-(N,N'-bis(tert-butyloxycarbonyl)guanyl)propyl)methanephosphonate

diphenyl N-benzyloxycarbonylamino-(3-(N,N'-bis(tert-butyloxycarbonyl)guanyl)propyl)methanephosphonate