24697-70-9

Basic information

• Product Name: 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione
• Synonyms: 2-(4-Hydroxybutyl)-1H-isoindole-1,3(2H)-dione;2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-(4-hydroxybutyl)-;2-(4-hydroxybutyl)isoindoline-1,3-dione(WXC02811)
• CAS NO: 24697-70-9
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.24
• Mol File: 24697-70-9.mol
• Article Data: 30

Chemical Properties

• Melting Point: 48-49 °C
• Boiling Point: 380.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.284±0.06 g/cm3(Predicted)
• PKA: 15.07±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione(24697-70-9)
• EPA Substance Registry System: 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione(24697-70-9)

Safety Data

• Hazardous Substances Data: 24697-70-9(Hazardous Substances Data)

Usage

General Description

2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione, also known as Indol-2-one, is a chemical compound with the molecular formula C10H11NO3. It is a derivative of isoindoline and contains a hydroxybutyl group attached to the nitrogen atom. 2-(4-Hydroxybutyl)-2H-isoindole-1,3-dione has been studied for its potential pharmacological properties, including its anti-inflammatory and antifungal activities. It has also been investigated for its potential as a building block in organic synthesis. Additionally, it has been reported to exhibit cytotoxic effects on cancer cells, making it an interesting compound for further research in the field of medicinal chemistry.

Upstream product

• 85-44-9 phthalic anhydride 
• 13325-10-5 4-Aminobutanol 

Downstream Products

• 86088-65-5 N-(4-hydroxy-1-butyl)phthalimide tosylate 
• 1515-72-6 N-butylphthalimide 
• 5457-30-7 4-phthalimido-1-iodobutane 
• 13325-10-5 4-Aminobutanol 
• 558444-72-7 (S)-2-[4-(5,6,7,8-tetrahydro-quinolin-8-ylamino)-butyl]-isoindole-1,3-dione 
• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 146548-64-3 [1-{[(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester 
• 176982-87-9 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile 
• 149194-43-4 diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate 
• 136604-50-7 2-amino-5-(2-phthalimidoethyl)thiazole hydrobromide 

Relevant articles and documents

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

Substituted imidazo[4,5-c]quinoline macrocyclic compound as multi-target kinase inhibitor

The invention discloses a substituted imidazo[4,5-c]quinoline macrocyclic compound as a multi-target kinase inhibitor, and relates to a compound represented by a formula (I) or a pharmaceutically acceptable salt, a solvate, a polymorphic substance or an isomer thereof, and applications of the compound in preparation of a medicine for treating ALK-mediated diseases.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.