phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

Base Information

Chemical Name:phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate
CAS No.:1193336-43-4
Molecular Formula:C₃₃H₃₂F₇N₃O₄
Molecular Weight:667.624
Hs Code.:

phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

Synonyms:phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

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Chemical Property of phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

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Technology Process of phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

There total 7 articles about phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1193336-42-3
phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate

: 1193336-43-4
phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

Guidance literature:: phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-propen-1-yl)-4-piperidinyl]carbamate; With ozone; In dichloromethane; at -78 ℃; Inert atmosphere;

With dimethylsulfide; In dichloromethane; at -78 ℃;

Reference yield:

: 414910-12-6
(2R)-2-(4-fluoro-2-methylphenyl)-4-piperidinone

: 1193336-43-4
phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: (S)-Mandelic acid; triethylamine / dichloromethane / 20 °C

2.1: ammonia / methanol / 0.25 h / 20 °C

2.2: 20 °C

3.1: dichloromethane / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

4.2: pH 8

5.1: triethylamine / ethyl acetate / 0 °C

5.2: 5.08 h / 0 °C / Reflux

6.1: ozone / dichloromethane / -78 °C / Inert atmosphere

6.2: -78 °C

With (S)-Mandelic acid; ammonia; ozone; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;

Reference yield:

: 629955-21-1
(2R)-2-(4-fluoro-2-methylphenyl)-4-oxo-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester

: 1193336-43-4
phenylmethyl [(2R,4S)-1-{[{[3,5-bis(trifluoromethyl)phenyl]methyl}(methyl)amino]carbonyl}-2-(4-fluoro-2-methylphenyl)-4-(2-oxoethyl)-4-piperidinyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia / methanol / 0.25 h / 20 °C

1.2: 20 °C

2.1: dichloromethane / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

3.2: pH 8

4.1: triethylamine / ethyl acetate / 0 °C

4.2: 5.08 h / 0 °C / Reflux

5.1: ozone / dichloromethane / -78 °C / Inert atmosphere

5.2: -78 °C

With ammonia; ozone; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;