Technology Process of 1-(tert-butyldiphenylsilyloxy)-5-methyl-3,4-hexadiene
There total 6 articles about 1-(tert-butyldiphenylsilyloxy)-5-methyl-3,4-hexadiene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methylmagnesium bromide;
With
copper(l) iodide; lithium chloride;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1h;
3-acetoxy-1-(tert-butyldiphenylsilyloxy)-4-hexyne;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 2h;
DOI:10.1248/cpb.48.405
- Guidance literature:
-
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol902675k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 95 percent / tetrahydrofuran / 3.5 h / 20 °C
2.1: 94 percent / Et3N; 4-dimethylaminopyridine / CH2Cl2 / 6 h / 20 °C
3.1: CuI; LiCl / diethyl ether; tetrahydrofuran / 1 h / -78 °C
3.2: 90 percent / diethyl ether; tetrahydrofuran / 2 h / -78 °C
With
dmap; copper(l) iodide; triethylamine; lithium chloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
1.1: Grignard reaction / 2.1: Acetylation / 3.1: complexation / 3.2: allenylation;
DOI:10.1248/cpb.48.405
