3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

Base Information

Chemical Name:3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide
CAS No.:872036-77-6
Molecular Formula:C₂₅H₂₆IN₃O₅
Molecular Weight:575.403
Hs Code.:

Synonyms:3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

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Chemical Property of 3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

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Technology Process of 3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

There total 5 articles about 3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 3-[1,3]dioxolo[4,5-g]quinolin-8-yl-2-(2-iodo-4,5-dimethoxy-phenyl)-acryloyl chloride

: 108-00-9
N,N-dimethylethylenediamine

: 872036-77-6
3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

Guidance literature:: With triethylamine; In dichloromethane; Heating;
DOI:10.1016/j.bmc.2005.07.033

Reference yield:

: 693263-06-8
3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid

: 872036-77-6
3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Heating

2: 97 percent / triethylamine / CH₂Cl₂ / Heating

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/j.bmc.2005.07.033

Reference yield:

: 14268-66-7
benzo[1,3]dioxolo-5-ylamine

: 872036-77-6
3-(6,7-methylenedioxyquinolin-4-yl)-2-(2-iodo-4,5-dimethoxyphenyl)acrylic acid 2-(N,N-dimethylamino)ethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 44 percent / iron(III) chloride; acetic acid / 1.5 h / Heating

2: 65 percent / SeO₂ / dioxane; H₂O / 4.5 h / Heating

3: 73 percent / acetic acid; triethylamine / 1.5 h / Heating

4: thionyl chloride / 3 h / Heating

5: 97 percent / triethylamine / CH₂Cl₂ / Heating

With selenium(IV) oxide; thionyl chloride; iron(III) chloride; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.bmc.2005.07.033