2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

Base Information

Chemical Name:2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt
CAS No.:1207460-32-9
Molecular Formula:C₂H₇N*C₂₅H₃₂FN₃O₆S
Molecular Weight:566.694
Hs Code.:

2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

Synonyms:2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

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Chemical Property of 2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

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Technology Process of 2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

There total 5 articles about 2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332363-97-9
2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

: 75-04-7,85404-22-4
ethylamine

: 1207460-32-9
2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

Guidance literature:: 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide; With methanol; sodium hydroxide; In dichloromethane; at 40 - 65 ℃;

ethylamine; In acetonitrile; at 0 - 35 ℃; for 1h; pH=8 - 9;

Reference yield:

: 1332363-93-5
(S)-5-hydroxy-N,N-dimethyl-3-oxo-6-(1-phenyl-1H-tetrazol-5-ylthio)hexanamide

: 1207460-32-9
2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: methyldiethoxyborane / tetrahydrofuran; methanol / -60 °C

1.2: 1 h

2.1: methanesulfonic acid / acetone / 12 h / 20 - 30 °C

3.1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / methanol / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / -78 - 35 °C / Inert atmosphere

5.1: sodium hydroxide; methanol / dichloromethane / 40 - 65 °C

5.2: 1 h / 0 - 35 °C / pH 8 - 9

With methanol; methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; methyldiethoxyborane; dihydrogen peroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetone;

Reference yield:

: 1332363-94-6
(3R,5S)-3,5-dihydroxy-N,N-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylthio)hexanamide

: 1207460-32-9
2-((4R,6S)-6-((E)-2-(4-(4'-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic acid ethyl amine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanesulfonic acid / acetone / 12 h / 20 - 30 °C

2.1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / methanol / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / -78 - 35 °C / Inert atmosphere

4.1: sodium hydroxide; methanol / dichloromethane / 40 - 65 °C

4.2: 1 h / 0 - 35 °C / pH 8 - 9

With methanol; methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetone;