2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

Base Information

Chemical Name:2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide
CAS No.:1332363-97-9
Molecular Formula:C₂₇H₃₇FN₄O₅S
Molecular Weight:548.679
Hs Code.:

2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

Synonyms:2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

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Chemical Property of 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

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Technology Process of 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

There total 4 articles about 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332363-96-8
2-((4R,6S)-2,2-dimethyl-6-((1-phenyl-1H-tetrazol-5-ylsulfonyl)methyl)-1,3-dioxan-4-yl)-N,N-dimethylacetamide

: 147118-37-4
N-[4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide

: 1332363-97-9
2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -78 - -70 ℃; for 8h; Inert atmosphere;

Reference yield:

: 1332363-93-5
(S)-5-hydroxy-N,N-dimethyl-3-oxo-6-(1-phenyl-1H-tetrazol-5-ylthio)hexanamide

: 1332363-97-9
2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate; methanol; diethoxymethylborane / -60 °C

2: methanesulfonic acid / 12 h / 30 °C

3: dihydrogen peroxide / hexaammonium heptamolybdate tetrahydrate / isopropyl alcohol; water / 25 °C

4: sodium hydride / tetrahydrofuran / 8 h / -78 - -70 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; diethoxymethylborane; dihydrogen peroxide; sodium hydride; methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; In tetrahydrofuran; water; isopropyl alcohol;

Reference yield:

: 1332363-94-6
(3R,5S)-3,5-dihydroxy-N,N-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylthio)hexanamide

: 1332363-97-9
2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: methanesulfonic acid / 12 h / 30 °C

2: dihydrogen peroxide / hexaammonium heptamolybdate tetrahydrate / isopropyl alcohol; water / 25 °C

3: sodium hydride / tetrahydrofuran / 8 h / -78 - -70 °C / Inert atmosphere

With dihydrogen peroxide; sodium hydride; methanesulfonic acid; hexaammonium heptamolybdate tetrahydrate; In tetrahydrofuran; water; isopropyl alcohol;