(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Base Information

Chemical Name:(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane
CAS No.:172170-16-0
Molecular Formula:C₃₄H₄₈O₄Si₂
Molecular Weight:576.924
Hs Code.:

Synonyms:(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Suppliers and Price of (2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

There total 11 articles about (2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 172277-22-4
Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

: 172170-16-0
(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Guidance literature:: With 1H-imidazole; In dichloromethane;
DOI:10.1016/0957-4166(95)00282-T

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 172170-16-0
(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / Zn dust / benzene / 1.5 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: Amano P lipase / various solvent(s) / 7 h / 33 °C / Enzymatic reaction

4: 97 percent / imidazole; 4-dimethylaminopyridine / CH₂Cl₂ / 44 h / 20 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; Amano P lipase; zinc; In tetrahydrofuran; dichloromethane; benzene; 1: Addition / 2: Reduction / 3: Acetylation / 4: Substitution;
DOI:10.1016/S0040-4020(98)00647-4

Reference yield:

: 172170-12-6
(+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

: 172170-16-0
(2S,3S)-1-acetoxy-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: 6.2 percent / Zn(BH₄)2-Et₂O / diethyl ether / 4 h / -20 °C

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: Amano P lipase / various solvent(s) / 7 h / 33 °C / Enzymatic reaction

4: 97 percent / imidazole; 4-dimethylaminopyridine / CH₂Cl₂ / 44 h / 20 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; Zn(BH₄)2*Et₂O; Amano P lipase; In tetrahydrofuran; diethyl ether; dichloromethane; 1: Reduction / 2: Reduction / 3: Acetylation / 4: Substitution;
DOI:10.1016/S0040-4020(98)00647-4