(+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

Base Information

• Chemical Name: (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate
• CAS No.: 172170-12-6
• Molecular Formula: C₁₇H₂₆O₄Si
• Molecular Weight: 322.477

Synonyms:(+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

Chemical Property of (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

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Technology Process of (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

There total 7 articles about (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(+/-)-methyl (2,3-syn)-3-hydroxy-3-(4-tert-butyldimethylsilyloxyphenyl)-2-methylpropanoate → (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate (172170-12-6)

Guidance literature:

With jones reagent; In acetone; at 0 ℃; for 0.666667h;

DOI:10.1016/S0040-4020(98)00647-4

Reference yield: 86.0%

3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propionic acid methyl ester → (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate (172170-12-6)

Guidance literature:

With chromium(VI) oxide; hydrogen cation;

DOI:10.1016/0957-4166(95)00282-T

Reference yield: 80.0%

methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate (501334-19-6) + methyl iodide (74-88-4) → (+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate (172170-12-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

upstream raw materials:

p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

4-hydroxy-benzaldehyde

tert-butyldimethylsilyl chloride

methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

Downstream raw materials:

(2S,3S,4S)-3-buten-1-yl 2-azido-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-<(tert-butyldiphenylsilyl)oxy>-3-methylbutanoate

(2S,3S,4S)-4-nitrophenyl 2-azido-4-<4-<(tert-butyldimethylsilyl)oxy>phenyl>-4-<(tert-butyldiphenylsilyl)oxy>-3-methylbutanoate

(2R,3S)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionaldehyde

(2S,3S)-3-(4-tert-butyldimethylsilyloxyphenyl)-3-tert-butyldiphenylsilyloxy-2-methylpropanol

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