Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

Base Information

Chemical Name:Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester
CAS No.:172277-22-4
Molecular Formula:C₁₈H₃₀O₄Si
Molecular Weight:338.519
Hs Code.:

Synonyms:Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

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Chemical Property of Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

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Technology Process of Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

There total 12 articles about Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 108-22-5
Isopropenyl acetate

: (+/-)-3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-1,3-propane diol

: Acetic acid (2R,3R)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

: 172277-22-4
Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

Guidance literature:: With Amano P lipase; In various solvent(s); at 33 ℃; for 7h; Title compound not separated from byproducts; Enzymatic reaction;
DOI:10.1016/S0040-4020(98)00647-4

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 172277-22-4
Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 36 percent / Zn dust / benzene / 1.5 h / Heating

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: Amano P lipase / various solvent(s) / 7 h / 33 °C / Enzymatic reaction

With lithium aluminium tetrahydride; Amano P lipase; zinc; In tetrahydrofuran; benzene; 1: Addition / 2: Reduction / 3: Acetylation;
DOI:10.1016/S0040-4020(98)00647-4

Reference yield:

: 172170-12-6
(+/-)-methyl 3-(4-tert-butyldimethylsilyloxyphenyl)-2-methyl-3-oxopropanoate

: 172277-22-4
Acetic acid (2S,3S)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-3-hydroxy-2-methyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 6.2 percent / Zn(BH₄)2-Et₂O / diethyl ether / 4 h / -20 °C

2: 76 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: Amano P lipase / various solvent(s) / 7 h / 33 °C / Enzymatic reaction

With lithium aluminium tetrahydride; Zn(BH₄)2*Et₂O; Amano P lipase; In tetrahydrofuran; diethyl ether; 1: Reduction / 2: Reduction / 3: Acetylation;
DOI:10.1016/S0040-4020(98)00647-4