(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Base Information

Chemical Name:(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine
CAS No.:288372-92-9
Molecular Formula:C₂₁H₃₁NO₂S
Molecular Weight:361.549
Hs Code.:

(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ<sup>5,6</sup>-indolizidine

Synonyms:(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Suppliers and Price of (-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

There total 10 articles about (-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-((S)-2-Chloro-1-methyl-ethyl)-1-{1-[1-(toluene-4-sulfonyl)-meth-(E)-ylidene]-hexyl}-pyrrolidine

: 288372-92-9
(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jo000080p

Reference yield:

: 212118-70-2
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propionic acid ethyl ester

: 288372-92-9
(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Guidance literature:: Multi-step reaction with 6 steps

1: 4.944 g / LiAlH₄ / diethyl ether / 1 h / 20 °C

2: 2.52 g / H₂ / 10percent Pd-C / ethanol / 144 h / 20 °C / 760.05 Torr

3: 70 percent / HCl; SOCl₂ / CHCl₃ / 3 h / Heating

4: KOH / H₂O

5: CH₂Cl₂ / 19 h / 20 °C

6: LDA / tetrahydrofuran / -78 °C

With hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; thionyl chloride; hydrogen; lithium diisopropyl amide; 10percent Pd-C; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; water; 1: Reduction / 2: dealkylation / 3: Chlorination / 4: exchange / 5: Addition / 6: Cyclization;
DOI:10.1021/jo000080p

Reference yield:

: 288373-07-9
(S)-2-[(S)-1-((R)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-propan-1-ol

: 288372-92-9
(-)-(8R,8aS)-8-methyl-5-n-pentyl-6-(p-toluenesulfonyl)-Δ^5,6-indolizidine

Guidance literature:: Multi-step reaction with 5 steps

1: 2.52 g / H₂ / 10percent Pd-C / ethanol / 144 h / 20 °C / 760.05 Torr

2: 70 percent / HCl; SOCl₂ / CHCl₃ / 3 h / Heating

3: KOH / H₂O

4: CH₂Cl₂ / 19 h / 20 °C

5: LDA / tetrahydrofuran / -78 °C

With hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; lithium diisopropyl amide; 10percent Pd-C; In tetrahydrofuran; ethanol; dichloromethane; chloroform; water; 1: dealkylation / 2: Chlorination / 3: exchange / 4: Addition / 5: Cyclization;
DOI:10.1021/jo000080p