2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid
CAS No.:1013328-63-6
Molecular Formula:C₃₁H₂₄N₂O₅
Molecular Weight:504.542
Hs Code.:

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Suppliers and Price of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Iris Biotech GmbH
Fmoc-L-Ala(2-Acd)-OH
50 mg
$ 283.50

Iris Biotech GmbH
Fmoc-L-Ala(2-Acd)-OH
500 mg
$ 1228.50

Iris Biotech GmbH
Fmoc-L-Ala(2-Acd)-OH
250 mg
$ 769.50

American Custom Chemicals Corporation
FMOC-ALA-(2-ACD)-OH 95.00%
5MG
$ 502.93

Total 2 raw suppliers

Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-L-Ala(2-Acd)-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

There total 6 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (S)-2-amino-3-(9-oxo-9,10-dihydroacridin-2-yl)propanoic acid

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1013328-63-6
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Guidance literature:: (S)-2-amino-3-(9-oxo-9,10-dihydroacridin-2-yl)propanoic acid; With triethylamine; In water; acetonitrile; for 0.75h; pH=8.5;

(fluorenylmethoxy)carbonyl chloride;
DOI:10.1021/ja3005094

Reference yield:

: C₂₂H₂₄N₂O₅

: 1013328-63-6
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / 2 h / 50 °C / pH 9

2: triethylamine / water; acetonitrile / 0.75 h / pH 8.5

With water; triethylamine; sodium hydroxide; In water; acetonitrile;
DOI:10.1021/ja3005094

Reference yield:

: 17193-40-7
(S)-4-nitrophenylalanine methyl ester hydrochloride

: 1013328-63-6
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(9-oxo-9,10-dihydro-acridin-2-yl)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate

2: palladium on activated charcoal; hydrogen

3: copper; potassium carbonate

4: polyphosphoric acid / 2 h / 140 °C

5: water; sodium hydroxide / 2 h / 50 °C / pH 9

6: triethylamine / water; acetonitrile / 0.75 h / pH 8.5

With palladium on activated charcoal; water; hydrogen; copper; sodium carbonate; potassium carbonate; triethylamine; sodium hydroxide; In water; acetonitrile;
DOI:10.1021/ja3005094