2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Base Information

Chemical Name:2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
CAS No.:931333-83-4
Molecular Formula:C₁₅H₁₉N₇
Molecular Weight:297.363
Hs Code.:

Synonyms:2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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Technology Process of 2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

There total 1 articles about 2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 931333-83-4
2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium methylate / ethanol / 24 h / Reflux

2: trichlorophosphate / 3 h / Inert atmosphere; Reflux

3: zinc; ammonium hydroxide / ethanol / 15 h / 78 °C

4: sodium carbonate / 1,4-dioxane / 30 h / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 16 h

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; sodium methylate; sodium carbonate; zinc; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.061

Reference yield: 88.0%

: 2785-98-0
2,5-dimethoxybenzoic acid

: 931333-83-4
2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1609485-38-2
(2,5-dimethoxyphenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8 dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.03.061

Reference yield: 87.0%

: 456-22-4
4-Fluorobenzoic acid

: 931333-83-4
2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1609485-39-3
(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.03.061