(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Base Information

Chemical Name:(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone
CAS No.:1609485-39-3
Molecular Formula:C₂₂H₂₂FN₇O
Molecular Weight:419.461
Hs Code.:

Synonyms:(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

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Chemical Property of (4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

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Technology Process of (4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

There total 6 articles about (4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 456-22-4
4-Fluorobenzoic acid

: 931333-83-4
2-(4-(pyrimidin-2-yl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1609485-39-3
(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2014.03.061

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 1609485-39-3
(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / ethanol / 24 h / Reflux

2: trichlorophosphate / 3 h / Inert atmosphere; Reflux

3: zinc; ammonium hydroxide / ethanol / 15 h / 78 °C

4: sodium carbonate / 1,4-dioxane / 30 h / 90 °C

5: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 16 h

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; sodium methylate; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.061

Reference yield:

: 135481-57-1
5,6,7,8-tetrahydro-6-(phenylmethyl)pyrido<3,4-d>pyrimidine-2,4(1H,3H)-dione

: 1609485-39-3
(4-fluorophenyl)(2-(4-(pyrimidin-2-yl)piperazin-1-yl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 3 h / Inert atmosphere; Reflux

2: zinc; ammonium hydroxide / ethanol / 15 h / 78 °C

3: sodium carbonate / 1,4-dioxane / 30 h / 90 °C

4: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 16 h

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With ammonium hydroxide; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; trichlorophosphate; In 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.03.061