tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

Base Information

Chemical Name:tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate
CAS No.:1217299-24-5
Molecular Formula:C₁₇H₁₉FN₄O₅
Molecular Weight:378.36
Hs Code.:

Synonyms:tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

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Chemical Property of tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

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Technology Process of tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

There total 3 articles about tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 884340-46-9
4-chloro-3-nitropyridin-2-N-methyl-amine

: 1217299-24-5
tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

Guidance literature:: N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

4-chloro-3-nitropyridin-2-N-methyl-amine; In dimethyl sulfoxide; mineral oil; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm900607f

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1217299-24-5
tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C

With sodium hydride; indium(III) chloride; In dimethyl sulfoxide; mineral oil;

Reference yield:

: 399-95-1
4-amino-3-fluorophenol

: 1217299-24-5
tert-butyl 2-fluoro-4-(2-(methylamino)-3-nitropyridin-4-yloxy)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: indium(III) chloride / 2 h / 35 °C / Neat (no solvent)

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C

With sodium hydride; indium(III) chloride; In dimethyl sulfoxide; mineral oil;