(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester
CAS No.:82979-10-0
Molecular Formula:C₁₅H₂₆O₅
Molecular Weight:286.368
Hs Code.:

Synonyms:(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Suppliers and Price of (1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

There total 4 articles about (1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 141-52-6
sodium ethanolate

: 82979-09-7
exo-7-carbethoxy-endo-9-methyl-2-oxabicyclo<4.3.1>decan-3-one

: 82979-10-0
(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: In ethanol; at 0 ℃; for 0.5h;
DOI:10.1021/ja00385a028

Reference yield:

: 82979-04-2
(E)-5-ethoxycarbonyl-4-pentenoic acid

: 82979-10-0
(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / red HgO, BF₃*Et₂O, MeOH / diethyl ether / 17 h / Ambient temperature

2: 100 mg / hydroquinone / benzene / 18 h / 185 - 188 °C

3: 95.4 percent / hydrogen / 10percentPd-C / ethyl acetate / 1.83 h / 0 °C

4: 100 percent / ethanol / 0.5 h / 0 °C

With methanol; boron trifluoride diethyl etherate; hydrogen; hydroquinone; mercury(II) oxide; 10% palladium on active carbon; In diethyl ether; ethanol; ethyl acetate; benzene;
DOI:10.1021/ja00385a028

Reference yield:

: 82979-05-3
ethyl 1-methylene-2-methyl-2-propenyl hex-2-enedioate

: 82979-10-0
(1S,2S,4R,5S)-2-(2-Ethoxycarbonyl-ethyl)-4-hydroxy-5-methyl-cyclohexanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 mg / hydroquinone / benzene / 18 h / 185 - 188 °C

2: 95.4 percent / hydrogen / 10percentPd-C / ethyl acetate / 1.83 h / 0 °C

3: 100 percent / ethanol / 0.5 h / 0 °C

With hydrogen; hydroquinone; 10% palladium on active carbon; In ethanol; ethyl acetate; benzene;
DOI:10.1021/ja00385a028