(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate

Base Information

• Chemical Name: (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate
• CAS No.: 129371-91-1
• Molecular Formula: C₂₄H₂₁NO₆
• Molecular Weight: 419.434
• Mol file: 129371-91-1.mol

Synonyms:(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate

Chemical Property of (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate

There total 4 articles about (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-4-bromo-3-phenylbut-2-enoate (129371-90-0) + potassium phtalimide (1074-82-4) → (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate (129371-91-1)

Guidance literature:

In N,N-dimethyl-formamide; at 140 ℃; for 1h;

DOI:10.1016/S0040-4020(01)82032-9

Reference yield:

(E)-3-phenyl-2-butenoic acid (704-80-3) → (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate (129371-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) thionyl chloride, 2.) pyridine / 1.) room temperature, 2.) methylene dichloride, room temperature

2: 83 percent / N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 6 h / Heating

3: 80 percent / dimethylformamide / 1 h / 140 °C

With pyridine; N-Bromosuccinimide; thionyl chloride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82032-9

Reference yield:

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate (129371-89-7) → (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate (129371-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 6 h / Heating

2: 80 percent / dimethylformamide / 1 h / 140 °C

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82032-9

upstream raw materials:

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-4-bromo-3-phenylbut-2-enoate

potassium phtalimide

(E)-3-phenyl-2-butenoic acid

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate

Downstream raw materials:

(S)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-butyric acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

(R)-4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-phenyl-butyric acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

(R)-Phenibut

(S)-Phenibut