(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate

Base Information

• Chemical Name: (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate
• CAS No.: 129371-89-7
• Molecular Formula: C₁₆H₁₈O₄
• Molecular Weight: 274.317
• Mol file: 129371-89-7.mol

Synonyms:(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate

Chemical Property of (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate

There total 1 articles about (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-phenyl-2-butenoic acid (704-80-3) + (R)-Pantolacton (599-04-2) → (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate (129371-89-7)

Guidance literature:

With pyridine; thionyl chloride; Yield given. Multistep reaction; 1.) room temperature, 2.) methylene dichloride, room temperature;

DOI:10.1016/S0040-4020(01)82032-9

Reference yield: 83.0%

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate (129371-89-7) → (R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-4-bromo-3-phenylbut-2-enoate (129371-90-0)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 6h; Heating;

DOI:10.1016/S0040-4020(01)82032-9

Reference yield:

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) E-3-phenylbut-2-enoate (129371-89-7) → (R)-Phenibut (1078-21-3,35568-36-6,62596-63-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / N-bromosuccinimide, dibenzoylperoxide / CCl₄ / 6 h / Heating

2: 80 percent / dimethylformamide / 1 h / 140 °C

3: hydrogen / 10percent palladium on charcoal / dioxane / 120 h / 760 Torr / Ambient temperature

4: 90 percent / 6M HCl / acetic acid / 10 h / Heating

With hydrogenchloride; N-Bromosuccinimide; hydrogen; dibenzoyl peroxide; palladium on activated charcoal; In 1,4-dioxane; tetrachloromethane; acetic acid; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)82032-9

upstream raw materials:

(E)-3-phenyl-2-butenoic acid

(R)-Pantolacton

Downstream raw materials:

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-4-bromo-3-phenylbut-2-enoate

(R)-(-)-2-(3,3-dimethylbutyro-1,4-lactonyl) Z-3-phenyl-4-phthalimidobut-2-enoate

(R)-Phenibut

(S)-Phenibut