129371-90-0Relevant articles and documents
A NEW SYNTHESIS, RESOLUTION AND IN VITRO ACTIVITIES OF (R)- AND (S)-β-PHENYL-GABA
Allan, R. D.,Bates, M. C.,Drew, C. A.,Duke, R. K.,Hambley, T. W.,et al.
, p. 2511 - 2524 (2007/10/02)
β-Phenyl-GABA (2) was resolved by separation by crystallization and/or h.p.l.c. of the diastereoisomeric (R)-(-)-pantolactone esters of the N-phthalimido protected β-phenyl-GABA.The absolute stereochemical assignments obtained from chiroptical studies of the enantiomers (8a) and (8b) and an X-ray crystallographic study of the diastereoisomer (7a) were supported by the activities of the enantiomers (8a) and (8b) in binding and electrophysiological studies.Details of synthesis, binding, electrophysiological, chiroptical and X-ray crystallographic studies are reported.