4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid
• CAS No.: 1262053-50-8
• Molecular Formula: C₁₀H₉BrO₃
• Molecular Weight: 263.018
• Mol file: 1262053-50-8.mol

Synonyms:4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid

Chemical Property of 4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid

There total 1 articles about 4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

succinic acid anhydride (108-30-5) + bromobenzene-1,2,3,4,5,6-13C6 (112630-77-0,287399-23-9) → 4-(4-bromo-(13)C6-phenyl)-4-oxobutanoic acid (1262053-50-8)

Guidance literature:

With aluminum (III) chloride; at 20 ℃; for 18h;

DOI:10.1002/jlcr.1798

Reference yield: 84.0%

4-(4-bromo-(13)C6-phenyl)-4-oxobutanoic acid (1262053-50-8) → 4-(4-bromo-(13)C6-phenyl)butanoic acid (1262053-51-9)

Guidance literature:

4-(4-bromo-⁽¹³⁾C₆-phenyl)-4-oxobutanoic acid; With potassium hydroxide; In water; diethylene glycol; for 0.5h;

With hydrazine hydrate; In water; diethylene glycol; at 20 - 180 ℃; for 21.5h; Inert atmosphere;

DOI:10.1002/jlcr.1798

Reference yield:

4-(4-bromo-(13)C6-phenyl)-4-oxobutanoic acid (1262053-50-8) → [1,2,3,4,4a,8a-(13)C6]naphthalene (287399-34-2,287399-39-7) + [1,2,3,4,4a,8a-(13)C6]naphthalen-2-ethanol (1262053-56-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium hydroxide / water; diethylene glycol / 0.5 h

1.2: 21.5 h / 20 - 180 °C / Inert atmosphere

2.1: polyphosphoric acid / 1.5 h / 90 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 1 h / 20 °C

4.1: toluene-4-sulfonic acid / toluene / 1.25 h / 70 - 75 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane / 1.25 h / 100 °C

6.1: n-butyllithium / diethyl ether; pentane / 0.08 h / Inert atmosphere

6.2: 0.5 h / Cooling with ice; Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; toluene; pentane; diethylene glycol; 1.2: Huang-Minlon reduction / 2.1: Friedel-Crafts acylation;

DOI:10.1002/jlcr.1798

upstream raw materials:

succinic acid anhydride

bromobenzene-1,2,3,4,5,6-¹³C₆

Downstream raw materials:

4-(4-bromo-⁽¹³⁾C₆-phenyl)butanoic acid

[1,2,3,4,4a,8a-(13)C6]naphthalene

[1,2,3,4,4a,8a-⁽¹³⁾C₆]naphthalen-2-ethanol