C₂₈H₂₄O₈

Base Information

• Chemical Name: C₂₈H₂₄O₈
• CAS No.: 86470-90-8
• Molecular Formula: C₂₈H₂₄O₈
• Molecular Weight: 488.494
• Mol file: 86470-90-8.mol

Synonyms:C₂₈H₂₄O₈

Chemical Property of C₂₈H₂₄O₈

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₂₈H₂₄O₈

There total 5 articles about C₂₈H₂₄O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(+)-Daunomycinone (21794-55-8) → 7-deoxydaunomycin (32384-98-8,35994-56-0) + C28H24O8 (86470-90-8)

Guidance literature:

With benzaldehyde; bis(3,5,5-trimethyl-2-oxomorpholin-3-yl); In deuteromethanol; at 25.1 ℃; trisma buffer (1:1 Tri/Tris-HCl);

DOI:10.1021/ja00353a062

Reference yield: 29.0%

7-deoxydaunomycinnone quinone methide (85337-17-3) + benzaldehyde (100-52-7) → 7-deoxydaunomycin (32384-98-8,35994-56-0) + C28H24O8 (86470-90-8)

Guidance literature:

With tris hydrochloride; 2-amino-2-hydroxymethyl-1,3-propanediol; In deuteromethanol; at 25.1 ℃;

DOI:10.1021/ja00320a027

Reference yield:

(+)-Daunomycinone (21794-55-8) + benzaldehyde (100-52-7) → C28H24O8 (86470-90-8)

Guidance literature:

With bis(3,5,5-trimethyl-2-oxomorpholin-3-yl); Yield given. Multistep reaction; 1.) methanol-O-d, trisma buffer (Tris/Tris-HCl), 25.1 deg C;

DOI:10.1021/ja00353a062

upstream raw materials:

(+)-Daunomycinone

benzaldehyde

7-deoxydaunomycinnone quinone methide

Downstream raw materials:

C₃₀H₂₆O₉

C₃₀H₂₆O₉

Refernces

• 1、 Kleyer,Koch. "Electrophilic trapping of the tautomer of 7-deoxydaunomycinone. A possible mechanism for covalent binding of daunomycin to DNA". . p. 5154 - 5155. Retrieved 2007/10/02.