(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

Base Information

Chemical Name:(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole
CAS No.:94820-27-6
Molecular Formula:C₄₆H₆₂N₂O₈Si
Molecular Weight:799.092
Hs Code.:

Synonyms:(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

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Chemical Property of (-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

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Technology Process of (-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

There total 9 articles about (-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 94820-26-5
(2S,3R)-2-(benzyloxycarbonylamino)-3-tertiary-butyldimethylsilyloxybutanoic acid

: 94820-25-4
(+)-(1R,2R,3S)-2-(1-n-butyl-2-isobutylcarbonyloxy-3-hydroxybutyl)-4,5-diphenyloxazole

: 94820-27-6
(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ja00291a059

Reference yield:

: 14224-99-8
2-methyl-4,5-diphenyloxazole

: 94820-27-6
(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / n-BiLi / tetrahydrofuran / -78 °C

2: 1) n-BuLi / 1) THF, -78 deg C

3: 74 percent / pyridine

4: 57 percent / boron trifluoride etherate, thiophenol

5: 95 percent / DCC, DMAP / CH₂Cl₂

With pyridine; dmap; n-butyllithium; boron trifluoride diethyl etherate; thiophenol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00291a059

Reference yield:

: 20662-96-8
2-n-pentyl-4,5-diphenyloxazole

: 94820-27-6
(-)-(1R,2R,3S)-2-(3-(N-benzyloxycarbonyl-O-t-butyldimethylsilyl-L-threonyloxy)-1-n-butyl-2-isobutylcarbonyloxybutyl)-4,5-diphenyloxazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1) n-BuLi / 1) THF, -78 deg C

2: 74 percent / pyridine

3: 57 percent / boron trifluoride etherate, thiophenol

4: 95 percent / DCC, DMAP / CH₂Cl₂

With pyridine; dmap; n-butyllithium; boron trifluoride diethyl etherate; thiophenol; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/ja00291a059