Technology Process of C13H11BrN4
There total 5 articles about C13H11BrN4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: LDA / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / -78 - 20 °C
2.1: SOCl2 / 3 h / 80 °C
3.1: aq. NH3 / tetrahydrofuran / 20 °C
4.1: SOCl2 / dimethylformamide / 16 h / 115 °C
5.1: hydrazine monohydrate / butan-1-ol / 5 h / 105 - 110 °C
6.1: Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 16 h / 90 °C
With
ammonium hydroxide; thionyl chloride; sodium carbonate; hydrazine hydrate; lithium diisopropyl amide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; butan-1-ol;
6.1: Suzuki coupling;
DOI:10.1021/jm061280h
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrazine monohydrate / butan-1-ol / 5 h / 105 - 110 °C
2: Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 16 h / 90 °C
With
sodium carbonate; hydrazine hydrate;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; toluene; butan-1-ol;
2: Suzuki coupling;
DOI:10.1021/jm061280h
- Guidance literature:
-
Multi-step reaction with 3 steps
1: SOCl2 / dimethylformamide / 16 h / 115 °C
2: hydrazine monohydrate / butan-1-ol / 5 h / 105 - 110 °C
3: Na2CO3 / Pd(PPh3)4 / toluene; ethanol; H2O / 16 h / 90 °C
With
thionyl chloride; sodium carbonate; hydrazine hydrate;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; water; N,N-dimethyl-formamide; toluene; butan-1-ol;
3: Suzuki coupling;
DOI:10.1021/jm061280h
