1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

Base Information

Chemical Name:1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine
CAS No.:1606991-86-9
Molecular Formula:C₁₇H₂₂N₈O₂S
Molecular Weight:402.48
Hs Code.:

Synonyms:1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

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Chemical Property of 1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

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Technology Process of 1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

There total 5 articles about 1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 109-01-3
1-methyl-piperazine

: 1606992-07-7
4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzene-1-sulfonyl chloride

: 1606991-86-9
1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

Guidance literature:: In acetonitrile; at 20 ℃;
DOI:10.1016/j.ejmech.2014.03.054

Reference yield:

: 682319-80-8
1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine

: 1606991-86-9
1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium permanganate; tetrabutylammomium bromide / acetic acid; benzene; water / 2 h / 20 °C

2: 216 h / 150 °C / Sealed tube

3: chlorosulfonic acid / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4: acetonitrile / 20 °C

With chlorosulfonic acid; potassium permanganate; tetrabutylammomium bromide; In water; acetic acid; acetonitrile; benzene;
DOI:10.1016/j.ejmech.2014.03.054

Reference yield:

: 871253-78-0
1,3-dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine

: 1606991-86-9
1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 216 h / 150 °C / Sealed tube

2: chlorosulfonic acid / 2 h / 20 °C / Inert atmosphere; Cooling with ice

3: acetonitrile / 20 °C

With chlorosulfonic acid; In acetonitrile;
DOI:10.1016/j.ejmech.2014.03.054