1606992-07-7

Upstream product

• 1606992-08-8 1,3-dimethyl-5-phenylamino-1H-pyrazolo[4,3-e][1,2,4]triazine 
• 871253-78-0 1,3-dimethyl-5-methylsulfonyl-1H-pyrazolo[4,3-e][1,2,4]triazine 
• 682319-80-8 1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine 
• 960307-19-1 C₇H₁₁N₅S 

Downstream Products

• 1606991-86-9 1,3-dimethyl-N-[4-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-87-0 1,3-dimethyl-N-(4-(morpholinosulfonyl)phenyl)-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-88-1 1,3-dimethyl-N-[4-(piperazin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-89-2 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(2-hydroxyethyl)benzenesulfonamide 
• 1606991-90-5 N-[4-(1,4-diazepan-1-ylsulfonyl)phenyl]-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-91-6 1,3-dimethyl-N-[4-(pyrrolidin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-92-7 1,3-dimethyl-N-[4-(piperidin-1-ylsulfonyl)phenyl]-1H-pyrazolo[4,3-e][1,2,4]triazin-5-amine 
• 1606991-93-8 N-(2-aminoethyl)-4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzenesulfonamide 
• 1606991-95-0 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide 
• 1606991-96-1 (1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(2-morpholinoethyl)benzenesulfonamide 
• 1606991-97-2 N-(2,3-dihydroxypropyl)-4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzenesulfonamide 
• 1606991-94-9 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

A new series of sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazine has been synthesized and characterized. Their anticancer activity was tested in vitro against multiple human cancer cell lines and were found to have dose-dependent antiproliferative effects. Furthermore, some of the new compounds inhibited the Abl protein kinase with low micromolar IC50 values and exhibited selective activity against the Bcr-Abl positive K562 and BV173 cell lines, providing starting points for the further development of this new kinase inhibitor scaffold.

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity

A series of sildenafil analogues and aniline substituted pyrazolo[4,3-e][1,2,4]triazine sulfonamides were prepared and evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors and for their anticancer activity against two human breast cancer cell lines (MCF-7, MDA-MB-231). The new compounds were ineffective as CA I inhibitors, poorly inhibited CA II, but were more effective against the tumor-associated isoforms CA IX and XII, with some compounds acting as low nanomolar inhibitors. Evaluation of the cytotoxicity by using an MTT assay, the inhibition of [3H]thymidine incorporation into DNA as well as collagen synthesis inhibition, demonstrated that these sulfonamides exhibit cytotoxic effects on breast cancer cell lines ex vivo.