N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

Base Information

Chemical Name:N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide
CAS No.:1188284-38-9
Molecular Formula:C₂₃H₁₈F₃N₅O₂
Molecular Weight:453.423
Hs Code.:

Synonyms:N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

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Chemical Property of N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

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Technology Process of N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

There total 7 articles about N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 585544-29-2
N-cyclopropyl-5-fluoro-4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzamide

: 1188285-09-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

: 1188284-38-9
N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: With sodium carbonate; In 1,4-dioxane; at 125 ℃; for 0.416667h; microwave irradiation;

Reference yield:

: 1188285-05-3
5-amino-1-(2,6-difluorophenyl)-1H-pyrazole-4-carbonitrile

: 1188284-38-9
N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / water / 10 h / Reflux

1.2: pH ~ 10 / Cooling with ice

2.1: hydrogenchloride; isopentyl nitrite / ethanol; ethyl acetate; isopropyl alcohol / 10 °C / Cooling with ice-NaCl

3.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

3.2: 4 h / Reflux

4.1: water; lithium hydroxide / acetonitrile / 20 - 60 °C

4.2: 20 °C / Cooling with ice

5.1: lithium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 20 °C

5.2: 18 h / 20 °C

6.1: sodium carbonate / 1,4-dioxane / 0.42 h / 125 °C / microwave irradiation

With hydrogenchloride; water; sodium ethanolate; lithium hydride; sodium carbonate; lithium hydroxide; isopentyl nitrite; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1-(2,6-difluorophenyl)hydrazine hydrochloride

: 1188284-38-9
N-cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[4,3-b]pyrazin-5-yl)-5-fluoro-4-methylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / ethanol / 1.67 h / 20 °C / Reflux

2.1: hydrogenchloride / water / 10 h / Reflux

2.2: pH ~ 10 / Cooling with ice

3.1: hydrogenchloride; isopentyl nitrite / ethanol; ethyl acetate; isopropyl alcohol / 10 °C / Cooling with ice-NaCl

4.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

4.2: 4 h / Reflux

5.1: water; lithium hydroxide / acetonitrile / 20 - 60 °C

5.2: 20 °C / Cooling with ice

6.1: lithium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 20 °C

6.2: 18 h / 20 °C

7.1: sodium carbonate / 1,4-dioxane / 0.42 h / 125 °C / microwave irradiation

With hydrogenchloride; water; sodium ethanolate; lithium hydride; sodium carbonate; triethylamine; lithium hydroxide; isopentyl nitrite; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;