5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

Base Information

Chemical Name:5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one
CAS No.:1188285-09-7
Molecular Formula:C₁₂H₇BrF₂N₄O
Molecular Weight:341.115
Hs Code.:

Synonyms:5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

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Chemical Property of 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

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Technology Process of 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

There total 6 articles about 5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

: 1188285-08-6
5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

: 74-88-4
methyl iodide

: 5-bromo-1-(2,6-difluorophenyl)-6-methoxy-1H-pyrazolo[3,4-b]pyrazine

: 1188285-09-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

Guidance literature:: 5-bromo-1-(2,6-difluorophenyl)-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one; With lithium hydride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 20 ℃;

methyl iodide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1-(2,6-difluorophenyl)hydrazine hydrochloride

: 1188285-09-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 1.67 h / 20 °C / Reflux

2.1: hydrogenchloride / water / 10 h / Reflux

2.2: pH ~ 10 / Cooling with ice

3.1: hydrogenchloride; isopentyl nitrite / ethanol; ethyl acetate; isopropyl alcohol / 10 °C / Cooling with ice-NaCl

4.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

4.2: 4 h / Reflux

5.1: water; lithium hydroxide / acetonitrile / 20 - 60 °C

5.2: 20 °C / Cooling with ice

6.1: lithium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 20 °C

6.2: 18 h / 20 °C

With hydrogenchloride; water; sodium ethanolate; lithium hydride; triethylamine; lithium hydroxide; isopentyl nitrite; In 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1188285-06-4
1-(2,6-difluorophenyl)-4-nitroso-1H-pyrazol-5-amine

: 1188285-09-7
5-bromo-1-(2,6-difluorophenyl)-7-methyl-1H-pyrazolo[4,3-b]pyrazin-6(7H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

1.2: 4 h / Reflux

2.1: water; lithium hydroxide / acetonitrile / 20 - 60 °C

2.2: 20 °C / Cooling with ice

3.1: lithium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 20 °C

3.2: 18 h / 20 °C

With water; sodium ethanolate; lithium hydride; lithium hydroxide; In 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; acetonitrile;