(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

Base Information

Chemical Name:(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester
CAS No.:218943-32-9
Molecular Formula:C₂₀H₂₆Cl₃NO₆
Molecular Weight:482.789
Hs Code.:

Synonyms:(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

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Chemical Property of (3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

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Technology Process of (3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

There total 4 articles about (3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 115-20-8
1,1,1-trichloroethanol

: 218943-30-7
(3S)-3-tert-butoxycarbonylamino-5-benzyloxycarbonylpentanoic acid

: 218943-32-9
(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1039/a805478i

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 218943-32-9
(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃ / tetrahydrofuran / 0.25 h / -25 °C

2: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

3: 71 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

4: 92 percent / DCC, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; water; silver trifluoroacetate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/a805478i

Reference yield:

: 128135-31-9
4-tert-butoxycarbonylamino-6-diazo-5-oxo-hexanoic acid benzyl ester

: 218943-32-9
(3S)-3-(tert-butoxycarbonylamino)hexanedioic acid 6-benzyl 1-(2,2,2-trichloroethyl) diester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

2: 92 percent / DCC, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; water; silver trifluoroacetate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1039/a805478i