({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

Base Information

Chemical Name:({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid
CAS No.:1198180-38-9
Molecular Formula:C₁₃H₁₃F₄NO₃
Molecular Weight:307.245
Hs Code.:

Synonyms:({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

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Chemical Property of ({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

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Technology Process of ({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

There total 2 articles about ({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1198181-18-8
1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol

: 3926-62-3
sodium monochloroacetic acid

: 1198180-38-9
({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

Guidance literature:: 1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-ol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60 ℃;

sodium monochloroacetic acid; With tetrabutylammomium bromide; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 40161-55-5
1-bromo-4-fluoro-2-(trifluoromethyl)benzene

: 1198180-38-9
({1-[4-fluoro-2-(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 60 °C

2.2: 1 h / 60 °C

With sodium hydride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; mineral oil;