2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide
CAS No.:1313043-33-2
Molecular Formula:C₂₇H₂₆F₇N₃O₃
Molecular Weight:573.511
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

There total 7 articles about 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

: 1313043-32-1
1-(2-methoxyethyl)-4-(trifluoromethyl)-1H-indole-3-carboxylic acid

: 1313043-33-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In Dichlorofluoromethane; at 20 ℃;

Reference yield:

: 202865-68-7
3-bromo-4-fluoro-benzylamine hydrochloride

: 1313043-33-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / Dichlorofluoromethane / 20 °C

With hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; Dichlorofluoromethane; water; isopropyl alcohol;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1313043-33-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / Dichlorofluoromethane / 20 °C

With hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; Dichlorofluoromethane; water; isopropyl alcohol;