[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

Base Information

Chemical Name:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride
CAS No.:1313040-69-5
Molecular Formula:C₂₅H₂₇F₄N₃O₂*ClH
Molecular Weight:513.963
Hs Code.:

Synonyms:[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

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Chemical Property of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

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Technology Process of [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

There total 8 articles about [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1313043-33-2
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

: 1313040-69-5
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indole-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide; With water; potassium carbonate; In methanol; at 20 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1313040-69-5
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / Dichlorofluoromethane / 20 °C

4.1: potassium carbonate; water / methanol / 20 °C

With water; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; Dichlorofluoromethane; water; isopropyl alcohol;

Reference yield:

: 202865-68-7
3-bromo-4-fluoro-benzylamine hydrochloride

: 1313040-69-5
[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-indol-3-yl]-methanone hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 11 h / 10 - 80 °C

1.2: 5 °C

1.3: 10 °C

2.1: hydrogen / platinum on carbon / methanol / 20 °C / 517.16 - 3102.97 Torr

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / Dichlorofluoromethane / 20 °C

4.1: potassium carbonate; water / methanol / 20 °C

With water; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In methanol; Dichlorofluoromethane; water; isopropyl alcohol;