diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

Base Information

Chemical Name:diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate
CAS No.:300661-83-0
Molecular Formula:C₂₆H₃₄N₂O₅
Molecular Weight:454.566
Hs Code.:

Synonyms:diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

Suppliers and Price of diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

Chemical Property:

Purity/Quality:: 99.9% ^*data from raw suppliers

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Technology Process of diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

There total 3 articles about diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 135099-82-0
C₂₆H₃₄N₂O₅

: 2743-38-6
O,O'-dibenzoyl-L-tartaric acid

: 300661-83-0,135099-82-0
diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

: diethyl 15aR-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate dibenzoyl-L-tartarate

Guidance literature:: In dichloromethane; at 30 ℃; for 1h;

Reference yield: 46.0%

: 135099-82-0
(+/-)-diethyl 15a-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

: 135099-82-0
diethyl 15aR-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

: 300661-83-0,135099-82-0
diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

Guidance literature:: With O,O'-dibenzoyl-L-tartaric acid; In ethanol; dichloromethane; at 20 ℃; for 2h;
DOI:10.3987/COM-00-8875

Reference yield:

: 1-(2,2-bis-ethoxycarbonyl-ethyl)-1-ethyl-2,3,4,6,7,12-hexahydro-1H-indolo[2,3-a]quinolizin-5-ylium; chloride

: 300661-83-0,135099-82-0
diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Et₃N / ethanol / 0.83 h / 50 °C

2: 46 percent / dibenzoyl-L-tartaric acid monohydrate / CH₂Cl₂; ethanol / 2 h / 20 °C

With triethylamine; O,O'-dibenzoyl-L-tartaric acid; In ethanol; dichloromethane; 1: Cycloaddition / 2: resolution;
DOI:10.3987/COM-00-8875