4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Base Information

• Chemical Name: 4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester
• CAS No.: 173606-56-9
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.251
• Mol file: 173606-56-9.mol

Synonyms:4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Chemical Property of 4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

97% purity ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

There total 1 articles about 4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

benzylidene-carbamic acid methyl ester (27593-61-9) + (1E)-3-{[tert-butyl(dimethyl)silyl]oxy}-N,N-dimethyl-1,3-butadien-1-amine (194233-66-4) → 4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (173606-56-9)

Guidance literature:

benzylidene-carbamic acid methyl ester; (1E)-3-{[tert-butyl(dimethyl)silyl]oxy}-N,N-dimethyl-1,3-butadien-1-amine; In dichloromethane; at -78 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; at 20 ℃; for 2h; Further stages.;

DOI:10.1021/ol006404d

Reference yield: 99.0%

4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (173606-56-9) → (R)-2-phenyl-2,3-dihydropyridin-4(1H)-one (201739-25-5)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol500498m

Reference yield: 93.0%

4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester (173606-56-9) → 5-Bromo-4-oxo-2-phenyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/0040-4039(95)01958-K

upstream raw materials:

benzylidene-carbamic acid methyl ester

(1E)-3-{[tert-butyl(dimethyl)silyl]oxy}-N,N-dimethyl-1,3-butadien-1-amine

Downstream raw materials:

(R)-2-phenyl-2,3-dihydropyridin-4(1H)-one

C₁₃H₁₃NO₃

C₁₆H₁₇NO₃

C₁₃H₁₃NO₃