(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

Base Information

Chemical Name:(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate
CAS No.:1450915-09-9
Molecular Formula:C₃₉H₂₇BrN₂O₃S
Molecular Weight:683.625
Hs Code.:

Synonyms:(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

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Chemical Property of (Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

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Technology Process of (Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

There total 3 articles about (Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1450915-09-9
(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 1 h / 0 - 5 °C

2: hydrazine hydrate / 6 h / 140 °C

3: piperidine / ethanol / 6 h / Reflux

4: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

With piperidine; copper peroxide; bromine; hydrazine hydrate; acetic acid; In ethanol; 2: |Wolff-Kishner Reduction / 3: |Knoevenagel Condensation / 4: |Ullmann Condensation;
DOI:10.1021/ol401527a

Reference yield:

: 20870-78-4
5-bromo-2-indolin-2-one

: 1450915-09-9
(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / ethanol / 6 h / Reflux

2: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

With piperidine; copper peroxide; In ethanol; 1: |Knoevenagel Condensation / 2: |Ullmann Condensation;
DOI:10.1021/ol401527a

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1450915-09-9
(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 6 h / 140 °C

2: piperidine / ethanol / 6 h / Reflux

3: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

With piperidine; copper peroxide; hydrazine hydrate; In ethanol; 1: |Wolff-Kishner Reduction / 2: |Knoevenagel Condensation / 3: |Ullmann Condensation;
DOI:10.1021/ol401527a