(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

Base Information

Chemical Name:(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid
CAS No.:1450915-11-3
Molecular Formula:C₃₈H₂₅BrN₂O₃S
Molecular Weight:669.598
Hs Code.:

Synonyms:(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

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Chemical Property of (Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

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Technology Process of (Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

There total 5 articles about (Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1450915-09-9
(Z)-methyl 4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoate

: 1450915-11-3
(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 6h;
DOI:10.1021/ol401527a

Reference yield:

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 1450915-11-3
(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / 6 h / 140 °C

2: piperidine / ethanol / 6 h / Reflux

3: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

4: sodium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

With piperidine; copper peroxide; water; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; ethanol; 1: |Wolff-Kishner Reduction / 2: |Knoevenagel Condensation / 3: |Ullmann Condensation;
DOI:10.1021/ol401527a

Reference yield:

: 1450915-08-8
(Z)-5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)-methylene)indolin-2-one

: 1450915-11-3
(Z)-4-(5-bromo-3-((5-(4-(diphenylamino)phenyl)thiophen-2-yl)methylene)-2-oxoindolin-1-yl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: copper peroxide / 20 h / Inert atmosphere; Sealed tube; Heating

2: sodium hydroxide; water / tetrahydrofuran / 6 h / 20 °C

With copper peroxide; water; sodium hydroxide; In tetrahydrofuran; 1: |Ullmann Condensation;
DOI:10.1021/ol401527a