N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine

Base Information

• Chemical Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine
• CAS No.: 99254-77-0
• Molecular Formula: C₂₀H₂₆INO₃
• Molecular Weight: 455.336
• Mol file: 99254-77-0.mol

Synonyms:N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine

Chemical Property of N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine

There total 2 articles about N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-methoxyphenyl)propan-2-one (3027-13-2) → N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine (99254-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / iodine, silver acetate / acetic acid / 3 h

2: p-toluenesulfonic acid / toluene / Heating

With iodine; silver(I) acetate; toluene-4-sulfonic acid; In acetic acid; toluene;

DOI:10.1021/jm00398a023

Reference yield:

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) + l-(2-iodo-5-methoxyphenyl)-2-propanone (99254-54-3) → N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine (99254-77-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1021/jm00398a023

Reference yield:

phenylacetylene (536-74-3) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + N-[2-(3,4-dimethoxyphenyl)ethyl]-2-iodo-5-methoxy-α-methylbenzeneethanamine (99254-77-0) → N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methoxy-α-methyl-2-(phenylethynyl)benzeneethanamine (E)-2-Butenedioate Hydrate

Guidance literature:

With n-butyllithium; Zinc chloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane;

upstream raw materials:

2-(3,4-dimethoxyphenyl)-ethylamine

l-(2-iodo-5-methoxyphenyl)-2-propanone

1-(3-methoxyphenyl)propan-2-one

Downstream raw materials:

[2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine

[2-(3,4-Dimethoxy-phenyl)-ethyl]-[2-(2-iodo-5-methoxy-phenyl)-1-methyl-ethyl]-methyl-amine

Butyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-[2-(5-methoxy-2-phenylethynyl-phenyl)-1-methyl-ethyl]-amine

[2-(3,4-Dimethoxy-phenyl)-ethyl]-{2-[2-(4-isopropyl-phenylethynyl)-5-methoxy-phenyl]-1-methyl-ethyl}-methyl-amine